Why is the risk of adenocarcinoma higher in Ulcerative Colitis compared to the general population?
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Correct answer: Long-standing chronic inflammation leading to dysplasia
The chronic inflammatory environment in IBD promotes epithelial turnover and oxidative stress, which can lead to DNA damage. This progresses through a low-grade to high-grade dysplasia-carcinoma sequence, necessitating regular colonoscopic surveillance.
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More Inflammatory Bowel Disease questions
- Which region of the gastrointestinal tract is most commonly involved in Crohn disease?
- What is the primary genetic association found in many patients with Crohn disease, involving intracellular bacteria sensing?
- Which of the following is true regarding smoking and IBD?
- Which of the following is a classic microscopic feature of 'chronic' IBD that indicates long-standing injury?
- Fissures in the bowel wall are most likely to lead to which clinical finding in Crohn disease?
- The 'Lead Pipe' sign in Ulcerative Colitis is due to: