Which histological change is most characteristic of the pancreatic islets in long-standing Type 2 Diabetes Mellitus?
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Correct answer: Amyloid deposition in pancreatic islets
Amyloidosis of the islets is a classic finding in Type 2 Diabetes. It results from the deposition of Amylin (Islet Amyloid Polypeptide), which is co-secreted with insulin and accumulates over time as beta cells are overworked.
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