Diabetes Mellitus · Pathology

Which renal lesion is considered pathognomonic (highly specific) for diabetic nephropathy?

  1. Mesangial sclerosis
  2. Kimmelstiel-Wilson nodules
  3. Focal segmental glomerulosclerosis
  4. Hyaline arteriolosclerosis
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Correct answer: Kimmelstiel-Wilson nodules

Kimmelstiel-Wilson nodules, or nodular glomerulosclerosis, are ovoid or spherical hyaline masses in the periphery of the glomerulus. They are highly specific for diabetes and occur in approximately 15-30% of long-term diabetic patients.

Difficulty: Medium Question 6 of 20

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