In the polyol pathway, glucose is converted to sorbitol by which enzyme, contributing to osmotic stress in the lens of the eye?
Show answer and explanation
Correct answer: Aldose reductase
In hyperglycemic states, aldose reductase converts excess glucose into sorbitol. Sorbitol is osmotically active and poorly metabolized, leading to water influx that causes cataracts in the lens and peripheral nerve damage.
Keep practicing
More Diabetes Mellitus questions
- Which renal lesion is considered pathognomonic (highly specific) for diabetic nephropathy?
- Diabetic ketoacidosis (DKA) is more common in Type 1 Diabetes because:
- What is the primary cause of Hyperosmolar Hyperglycemic State (HHS) in Type 2 Diabetes?
- Which of the following describes 'Insulitis'?
- A diabetic patient presents with 'stocking-glove' sensory loss. This is primarily due to:
- Gestational diabetes increases the risk of which neonatal complication?