Interstitial Growth · Histology

Which of the following characterizes the 'Zone of Proliferation' in the epiphyseal plate?

  1. Chondrocytes are dying and the surrounding matrix is becoming calcified.
  2. Mesenchymal cells are actively differentiating into chondroblasts.
  3. Chondrocytes divide rapidly and form organized longitudinal columns.
  4. The existing cartilage matrix is being replaced by woven bone.
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Correct answer: Chondrocytes divide rapidly and form organized longitudinal columns.

The zone of proliferation is a key site of interstitial growth. The repeated divisions of chondrocytes in this area create the vertical columns that drive the lengthening of the bone.

Difficulty: Medium Question 7 of 20

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