Microscopy Resolution · Histology

Contrast and resolution are often in a trade-off. Which action increases contrast but potentially reduces resolution?

  1. Increasing the brightness of the bulb
  2. Using a higher NA objective
  3. Using a blue filter
  4. Closing the iris diaphragm
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Correct answer: Closing the iris diaphragm

Closing the iris diaphragm increases contrast by reducing stray light and narrowing the light cone, but this decreases the effective NA, which negatively impacts the resolving power.

Difficulty: Medium Question 16 of 20

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