What is the function of TFIIH in the eukaryotic transcription pre-initiation complex?
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Correct answer: It has helicase activity to unwind DNA and kinase activity to phosphorylate the CTD
TFIIH is a multi-subunit general transcription factor. Its helicase activity creates the transcription bubble, while its kinase activity phosphorylates the RNA polymerase II CTD to trigger promoter clearance and the elongation phase.
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