In prokaryotes, Rho-independent termination is characterized by the formation of what in the nascent RNA?
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Correct answer: A GC-rich hairpin followed by a U-rich stretch
Rho-independent (intrinsic) termination involves a GC-rich palindromic sequence that folds into a hairpin in the nascent RNA, stalling RNA polymerase. The downstream A-U base pairs in the DNA-RNA hybrid are then too weak to hold the transcript, causing dissociation.
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