In eukaryotes, the 'Pre-Replication Complex' is licensed during which phase of the cell cycle?
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Correct answer: G1 phase
To ensure DNA is replicated only once per cycle, the Origin Recognition Complex (ORC) and licensing factors (Mcm2-7) assemble at origins during G1. This 'licensing' step is inactivated once the cell enters S phase, preventing re-replication.
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