During replication, which of the following provides the energy required for the formation of the phosphodiester bond?
Show answer and explanation
Correct answer: Cleavage of pyrophosphate from incoming dNTPs
Each incoming deoxynucleoside triphosphate (dNTP) donates its alpha-phosphate to form the phosphodiester bond. The subsequent hydrolysis of the released pyrophosphate (PPi) by pyrophosphatase drives the reaction forward thermodynamically.
Practice all 20 DNA Replication: Mechanisms and Enzymes questions
Keep practicing
More DNA Replication: Mechanisms and Enzymes questions
- Which eukaryotic DNA polymerase is primarily responsible for the synthesis of the lagging strand?
- The direction of DNA synthesis is always:
- What is a 'Replisome'?
- In eukaryotes, the 'Pre-Replication Complex' is licensed during which phase of the cell cycle?
- Which enzyme is unique for its ability to synthesize a DNA strand using an RNA template?
- What happens to the histones in eukaryotic cells during DNA replication?