What is the role of the 'Sliding Clamp' (beta-subunit in E. coli) in DNA replication?
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Correct answer: To keep DNA polymerase attached to the template strand
The sliding clamp (beta-subunit in E. coli; PCNA in eukaryotes) encircles the DNA and tethers DNA polymerase to the template, dramatically increasing its processivity so it can synthesize thousands of nucleotides without falling off.
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More DNA Replication: Mechanisms and Enzymes questions
- During replication, which of the following provides the energy required for the formation of the phosphodiester bond?
- Which eukaryotic DNA polymerase is primarily responsible for the synthesis of the lagging strand?
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- In eukaryotes, the 'Pre-Replication Complex' is licensed during which phase of the cell cycle?
- Which enzyme is unique for its ability to synthesize a DNA strand using an RNA template?