Where is the 'stem cell niche' located in the mammalian small intestine for the continuous renewal of the epithelial lining?
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Correct answer: The crypts of Lieberkühn
The crypts of Lieberkühn house Lgr5+ intestinal stem cells at their base. These cells divide to produce transit-amplifying cells that migrate upward along the villus, differentiating as they go and replacing cells shed from the villus tips.
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