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Animal Stem Cells and Regeneration · Zoology

The 'Stem Cell Niche' refers to:

  1. The physical location where stem cells are isolated and maintained in a laboratory culture dish
  2. The specific microenvironment that regulates stem cell self-renewal and differentiation
  3. The cellular process by which a normal stem cell acquires mutations and transforms into a cancer cell
  4. The total population of all stem cells distributed throughout the tissues of an adult organism
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Correct answer: The specific microenvironment that regulates stem cell self-renewal and differentiation

The stem cell niche consists of neighboring support cells, extracellular matrix components, and paracrine signaling molecules that collectively maintain stem cell quiescence or controlled proliferation. When stem cells leave the niche, they typically begin differentiating.

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