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Animal Stem Cells and Regeneration · Zoology

What happens during the 'dedifferentiation' phase of epimorphic limb regeneration?

  1. Cells migrate to the wound surface and are eliminated by programmed apoptosis
  2. Specialized cells such as muscle fibers lose their differentiated state to become proliferative progenitor cells
  3. The animal undergoes a full molt that initiates replacement limb tissue
  4. The remaining skeletal elements elongate by endochondral bone growth to fill the gap
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Correct answer: Specialized cells such as muscle fibers lose their differentiated state to become proliferative progenitor cells

Dedifferentiation involves mature, specialized cells reverting to a simpler progenitor state to form the blastema. This restores a pool of proliferative cells that can subsequently re-differentiate into the various tissues of the regenerated limb.

Difficulty: Medium Question 11 of 20

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