Animal Stem Cells and Regeneration · Zoology

Which of these is a significant ethical advantage of using iPSCs compared to ESCs?

  1. iPSCs can be expanded in culture more easily and in far greater quantities than ESCs
  2. iPSCs do not require the destruction of a human embryo to derive
  3. iPSCs accumulate no somatic mutations and maintain perfect genomic stability
  4. iPSCs are restricted to experimental animal models and cannot be used in humans
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Correct answer: iPSCs do not require the destruction of a human embryo to derive

Because iPSCs are generated by reprogramming adult somatic cells such as skin fibroblasts or blood cells, their derivation avoids the ethical controversy surrounding the use and destruction of human blastocysts. They additionally offer the advantage of being immunologically matched to the donor.

Difficulty: Medium Question 16 of 20

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