In amphibians, what is the 'Apical Epithelial Cap' (AEC)?
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Correct answer: A thickened epidermal layer at the wound site that is essential for blastema formation and limb regeneration
The Apical Epithelial Cap (AEC) forms rapidly after amputation and secretes fibroblast growth factors (FGFs) that sustain the underlying mesenchymal cells in a proliferative, undifferentiated state. Removal of the AEC prevents blastema formation and halts regeneration.
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