Which of the following best describes 'DNA laddering' observed in apoptotic cells?
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Correct answer: Cleavage of DNA into 180-200 bp internucleosomal multiples
Activated endonucleases cleave the DNA at internucleosomal linker regions during apoptosis. This results in DNA fragments that are multiples of the nucleosome length, appearing as a characteristic 'ladder' on an electrophoresis gel.
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More Apoptosis and Its Significance questions
- The extrinsic pathway of apoptosis is initiated by the binding of ligands to which type of receptors?
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- Which of the following is considered an anti-apoptotic protein?
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