The release of which molecule from the mitochondria is required to form the apoptosome in the cytosol?
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Correct answer: Cytochrome c
Cytochrome c, normally involved in the electron transport chain, is released into the cytoplasm during apoptosis. It binds to Apaf-1 and procaspase-9 to form the apoptosome complex, which activates initiator caspases.
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More Apoptosis and Its Significance questions
- Which of the following best describes 'DNA laddering' observed in apoptotic cells?
- The extrinsic pathway of apoptosis is initiated by the binding of ligands to which type of receptors?
- Which phospholipid moves from the inner to the outer leaflet of the plasma membrane, acting as an 'eat-me' signal for phagocytes?
- In the context of cancer, how do mutations in the p53 gene typically affect apoptosis?
- Which of the following is considered an anti-apoptotic protein?
- What happens to the apoptotic bodies formed at the end of the apoptotic process?