The 'intrinsic pathway' of apoptosis is primarily regulated by which organelle?
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Correct answer: Mitochondrion
The intrinsic or mitochondrial pathway is triggered by internal cellular stress, leading to mitochondrial outer membrane permeabilization. This results in the release of pro-apoptotic factors like Cytochrome c into the cytosol.
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More Apoptosis and Its Significance questions
- Which family of proteins acts as the primary 'molecular switch' to either promote or inhibit apoptosis?
- During the execution phase of apoptosis, which enzymes are responsible for the deliberate proteolysis of cellular components?
- What is the biological significance of apoptosis during vertebrate limb development?
- The release of which molecule from the mitochondria is required to form the apoptosome in the cytosol?
- Which of the following best describes 'DNA laddering' observed in apoptotic cells?
- The extrinsic pathway of apoptosis is initiated by the binding of ligands to which type of receptors?