Thermoregulation and Body Fluids · USMLE Step 1

A patient with heat stroke presents with confusion and a core body temperature of 41.5°C (106.7°F). Which physiological mechanism is primarily overwhelmed in classic heat stroke?

  1. Cutaneous vasoconstriction response
  2. Evaporative heat loss via sweating
  3. Shivering-based thermogenesis
  4. Nonshivering thermogenesis pathway
Show answer and explanation

Correct answer: Evaporative heat loss via sweating

Heat stroke occurs when evaporative heat loss via sweating becomes insufficient to dissipate heat. This leads to uncontrolled rise in core temperature and CNS dysfunction.

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