Thermoregulation and Body Fluids · USMLE Step 1

A patient is given 2 liters of isotonic saline. Which compartment increases the most?

  1. Intracellular fluid
  2. Extracellular fluid
  3. Plasma only
  4. Interstitial fluid only
Show answer and explanation

Correct answer: Extracellular fluid

Isotonic saline expands the extracellular fluid compartment because it does not cross cell membranes. Both plasma and interstitial fluid increase.

Difficulty: Medium Question 4 of 20

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