Which toxic effect is most characteristic of platinum-based agents like cisplatin or carboplatin?
Show answer and explanation
Correct answer: Nephrotoxicity and neurotoxicity
Platinum-based agents are associated with nephrotoxicity and cumulative neurotoxicity (especially peripheral neuropathy) because of their platinum–DNA binding and uptake in kidney and neural tissues.
Keep practicing
More Chemotherapy and Toxicology questions
- Which chemotherapy drug class mimics normal nucleotides to block DNA synthesis during S-phase?
- Which of the following is a major dose-limiting toxicity of many chemotherapy agents affecting rapidly dividing bone marrow cells?
- A patient develops hemorrhagic cystitis after chemotherapy with cyclophosphamide. Which metabolite is primarily responsible?
- Which chemotherapy drug class interferes with microtubule function, preventing mitosis by disrupting the mitotic spindle?
- Which of the following is a well-known cardiotoxic chemotherapy agent often limited by cumulative dose?
- Which anti-cancer drug class exerts its effect by inhibiting topoisomerase enzymes, thus preventing DNA unwinding and replication?