A patient develops hemorrhagic cystitis after chemotherapy with cyclophosphamide. Which metabolite is primarily responsible?
Show answer and explanation
Correct answer: Acrolein
Cyclophosphamide is metabolized to acrolein, which is urotoxic and causes hemorrhagic cystitis.
Keep practicing
More Chemotherapy and Toxicology questions
- Which chemotherapy drug class interferes with microtubule function, preventing mitosis by disrupting the mitotic spindle?
- Which of the following is a well-known cardiotoxic chemotherapy agent often limited by cumulative dose?
- Which anti-cancer drug class exerts its effect by inhibiting topoisomerase enzymes, thus preventing DNA unwinding and replication?
- Which adverse effect is most characteristic of bleomycin therapy?
- Which of the following statements regarding chemotherapy resistance is correct?
- Which organ system is especially vulnerable to toxic effects of chemotherapy due to high turnover of cells and drug metabolism?