Which chemotherapy drug class mimics normal nucleotides to block DNA synthesis during S-phase?
Show answer and explanation
Correct answer: Antimetabolites
Antimetabolites resemble nucleotides or nucleotide precursors and get incorporated into DNA/RNA or inhibit synthesis pathways, thus blocking replication during S phase.
Keep practicing
More Chemotherapy and Toxicology questions
- Which of the following is a major dose-limiting toxicity of many chemotherapy agents affecting rapidly dividing bone marrow cells?
- A patient develops hemorrhagic cystitis after chemotherapy with cyclophosphamide. Which metabolite is primarily responsible?
- Which chemotherapy drug class interferes with microtubule function, preventing mitosis by disrupting the mitotic spindle?
- Which of the following is a well-known cardiotoxic chemotherapy agent often limited by cumulative dose?
- Which anti-cancer drug class exerts its effect by inhibiting topoisomerase enzymes, thus preventing DNA unwinding and replication?
- Which adverse effect is most characteristic of bleomycin therapy?