Chemotherapy and Toxicology · USMLE Step 1

Which of the following statements regarding chemotherapy resistance is correct?

  1. Combination therapy reliably reverses single-agent resistance
  2. Resistance mechanisms include decreased drug uptake and increased DNA repair
  3. Resistance is limited to the alkylating agent class
  4. Resistance is absent in non-dividing tumor cells
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Correct answer: Resistance mechanisms include decreased drug uptake and increased DNA repair

Resistance mechanisms include reduced drug accumulation, enhanced drug inactivation, increased DNA repair, and other mechanisms. This is common across many classes.

Difficulty: Medium Question 10 of 20

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