Inflammation and repair · USMLE Step 1

Which event signals the beginning of the remodeling (maturation) phase of wound repair?

  1. Initial fibrin clot formation
  2. Neutrophil infiltration of the wound
  3. Granulation tissue formation
  4. Type III collagen replaced by type I
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Correct answer: Type III collagen replaced by type I

During remodeling, the provisional ECM is reorganized — type III collagen is replaced by stronger type I collagen, and collagen fibers are reoriented to increase tissue strength.

Difficulty: Medium Question 13 of 22

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