Genetic and Pediatric Diseases · USMLE Step 1

A newborn male baby presents with micrognathia, downward slanting palpebral fissures, malformed ears and cleft palate, but normal intelligence. Which disorder is most consistent with these findings?

  1. Turner syndrome
  2. Treacher Collins syndrome
  3. Down syndrome
  4. Prader–Willi syndrome
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Correct answer: Treacher Collins syndrome

Treacher Collins syndrome is an autosomal dominant craniofacial disorder characterized by mandibulofacial dysostosis — normal intelligence but ear, cheekbone, jaw, palate and ear anomalies.

Difficulty: Medium Question 16 of 20

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