Cell injury and death · USMLE Step 1

A patient with hypoxic injury shows cellular swelling. What is the primary cause of this change?

  1. Increased anaerobic glycolysis
  2. Failure of Na+/K+ pump
  3. Protein leakage
  4. DNA fragmentation
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Correct answer: Failure of Na+/K+ pump

ATP depletion impairs the Na+/K+ pump, causing intracellular sodium and water accumulation.

Difficulty: Medium Question 12 of 20

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