Musculoskeletal and Skin: Osteoporosis, Psoriasis Practice Questions
20 free Musculoskeletal and Skin: Osteoporosis, Psoriasis practice questions for the USMLE Step 1, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.
Questions
20 questions
All Musculoskeletal and Skin: Osteoporosis, Psoriasis questions
- Q1. A 72-year-old woman presents with a hip fracture after a minor fall. DEXA scan shows a T-score of –2.8. Which pathophysiologic process is most characteristic o…
- Q2. A patient with psoriasis develops silvery scales on extensor surfaces. Which histologic feature is classically seen?
- Q3. Which factor increases a patient’s risk of developing osteoporosis?
- Q4. A patient with psoriasis experiences worsening symptoms after streptococcal pharyngitis. Which type of hypersensitivity is implicated?
- Q5. Which medication reduces the risk of vertebral and hip fractures in osteoporosis by inhibiting osteoclast activity?
- Q6. A patient with psoriasis asks about nail findings associated with the disease. Which finding is characteristic?
- Q7. A postmenopausal woman begins estrogen replacement therapy. How does estrogen affect bone physiology?
- Q8. Which cytokine plays a major role in the pathogenesis of psoriasis?
- Q9. A patient presents with vertebral compression fractures. Which lab abnormality is expected in primary osteoporosis?
- Q10. A patient with psoriasis is started on a TNF-α inhibitor. What is the major risk of this therapy?
- Q11. A 65-year-old woman with osteoporosis begins teriparatide therapy. What is its mechanism?
- Q12. A pediatric patient with guttate psoriasis presents after a recent streptococcal infection. What is the typical distribution of lesions?
- Q13. A patient presents with low-trauma fractures. Which lifestyle factor contributes most strongly to osteoporosis?
- Q14. Which finding is characteristic of psoriatic arthritis rather than osteoarthritis?
- Q15. A patient with osteoporosis begins denosumab therapy. Which pathway is targeted?
- Q16. Which of the following nail findings is MOST specific for psoriasis?
- Q17. A 60-year-old woman develops vertebral fractures despite adequate calcium intake. Her labs show low vitamin D levels. What is the mechanism?
- Q18. A biopsy of a psoriatic plaque shows parakeratosis. What does this indicate?
- Q19. Which comorbidity is strongly associated with psoriasis due to chronic systemic inflammation?
- Q20. A patient with osteoporosis sustains a Colles fracture. This involves which bone?