Musculoskeletal and Skin: Osteoporosis, Psoriasis · USMLE Step 1

A 72-year-old woman presents with a hip fracture after a minor fall. DEXA scan shows a T-score of –2.8. Which pathophysiologic process is most characteristic of osteoporosis?

  1. Globally decreased osteoclast activity
  2. Markedly increased osteoblast activity
  3. Normal mineralization, low bone mass
  4. Defective osteoid matrix formation
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Correct answer: Normal mineralization, low bone mass

Osteoporosis is characterized by normal mineralization but reduced total bone mass. Bone microarchitecture deteriorates, predisposing to fractures.

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