Musculoskeletal and Skin: Osteoporosis, Psoriasis · USMLE Step 1

A 65-year-old woman with osteoporosis begins teriparatide therapy. What is its mechanism?

  1. Continuous PTH exposure to increase bone resorption
  2. Intermittent PTH exposure to increase bone formation
  3. Inhibition of osteoblast differentiation
  4. Increase in RANKL production
Show answer and explanation

Correct answer: Intermittent PTH exposure to increase bone formation

Intermittent PTH analog use stimulates osteoblasts more than osteoclasts, promoting bone formation. Continuous exposure has opposite effects.

Difficulty: Medium Question 11 of 20

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