Ultrastructure of cells · USMLE Step 1

What does the term “cell ultrastructure” refer to in histology and cell biology?

  1. The gross anatomy of organs seen under a light microscope
  2. The submicroscopic architecture of cells and organelles seen by electron microscopy
  3. The pattern of gene expression within an individual cell
  4. The spatial distribution of tissues throughout an organ
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Correct answer: The submicroscopic architecture of cells and organelles seen by electron microscopy

Cell ultrastructure refers to the detailed internal organization of cells (organelles, membranes, cytoskeleton) that can be seen only at very high magnifications — typically using electron microscopy — beyond the resolution of light microscopy.

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