Ultrastructure of cells · USMLE Step 1

Which organelle appears as a dark, dense spherical region within the nucleus on electron micrographs and is the site of ribosomal subunit assembly?

  1. Nucleolus
  2. Centrosome
  3. Peroxisome
  4. Lysosome
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Correct answer: Nucleolus

The nucleolus is a dense region within the nucleus that lacks a membrane; under electron microscopy it appears as a dark sphere and is the site where ribosomal RNA is transcribed and ribosomal subunits assemble.

Difficulty: Medium Question 11 of 21

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