Stem Cells and Regeneration · USMLE Step 1

Which of the following is a defining characteristic of a true stem cell?

  1. Having a fixed, specialized function within a tissue
  2. A complete inability to divide after birth
  3. Self-renewal and differentiation into other cell types
  4. Permanent residence in the G0 phase of the cell cycle
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Correct answer: Self-renewal and differentiation into other cell types

Stem cells are undifferentiated cells that can self-renew (i.e. make more stem cells) and differentiate into specialized cell types — allowing tissue maintenance and repair.

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