Histopathology basics · USMLE Step 1

Which of the following features is most characteristic of a benign neoplasm (tumor) as compared to a malignant tumor under the microscope?

  1. High mitotic activity and marked nuclear pleomorphism
  2. Invasion through the underlying basement membrane
  3. Well-differentiated, minimally atypical cells within a capsule
  4. Metastatic spread to distant organ sites
Show answer and explanation

Correct answer: Well-differentiated, minimally atypical cells within a capsule

Benign tumors typically consist of well-differentiated cells that resemble normal tissue, usually grow slowly, and are often encapsulated; they lack invasive behavior and metastatic potential, unlike malignant tumors.

Difficulty: Medium Question 6 of 22

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