Histopathology basics · USMLE Step 1

Which of the following best defines the term Neoplasia in histopathology?

  1. A reversible adaptation to stress where cells change type
  2. Ordered regenerative proliferation after tissue injury
  3. Abnormal, unregulated cell growth that forms a persistent mass
  4. Normal hyperplastic response to hormonal stimulation
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Correct answer: Abnormal, unregulated cell growth that forms a persistent mass

Neoplasia refers to abnormal, excessive and unregulated cell proliferation forming a mass (neoplasm), which persists even after the initiating stimulus is removed — distinguishing it from adaptive or physiologic hyperplasia.

Difficulty: Medium Question 10 of 22

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