Cytoskeleton and motility · USMLE Step 1

Which of the following cytoskeletal processes would most likely be impaired by a toxin that inhibits tubulin polymerization?

  1. Muscle contraction mediated by actin-myosin
  2. Cell migration via lamellipodia formation
  3. Chromosome segregation during mitosis
  4. Intermediate filament-based cell support
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Correct answer: Chromosome segregation during mitosis

Inhibition of tubulin polymerization prevents formation of microtubules, thereby disrupting the mitotic spindle necessary for chromosome segregation during mitosis.

Difficulty: Medium Question 15 of 21

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