Cytoskeleton and motility · USMLE Step 1

Which cytoskeletal element and associated molecular motors are primarily responsible for retrograde (toward nucleus) vesicular transport in neurons?

  1. Actin filaments with myosin I
  2. Microtubules with dynein
  3. Intermediate filaments with keratin
  4. Collagen fibers with adhesion proteins
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Correct answer: Microtubules with dynein

Microtubules serve as tracks for retrograde transport in neurons, with dynein motor proteins carrying vesicles from distal axon toward the nucleus/cell body.

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