Cytoskeleton and motility · USMLE Step 1

Which cytoskeletal alteration would most likely impair endocytosis and exocytosis processes dependent on vesicle transport?

  1. Loss of intermediate filament proteins from the cytoplasm
  2. Stabilizing the actin cortex so it can no longer remodel
  3. Excessive microtubule polymerization throughout cytoplasm
  4. Complete absence of nuclear lamins from the envelope
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Correct answer: Stabilizing the actin cortex so it can no longer remodel

Dynamic remodeling of actin filaments near the plasma membrane is essential for endocytosis and exocytosis; if the actin cortex becomes overly stabilized and rigid, vesicle docking and membrane remodeling are hindered.

Difficulty: Medium Question 19 of 21

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