During directed cell migration, which cytoskeletal filament system and associated dynamics are mainly responsible for establishing cell polarity (front–rear axis)?
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Correct answer: Leading-edge actin protrusions with rear microtubule reorientation
Cell polarity during migration depends on actin-driven protrusive structures at the leading edge and coordinated microtubule reorientation that helps organize intracellular trafficking and rear retraction — both cytoskeletal networks are critical.
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