Genetic Testing and Counseling · USMLE Step 1

During pre-test genetic counseling, why must the possibility of incidental (secondary) findings be discussed?

  1. Because such findings always turn out to have no clinical relevance
  2. Because patients may uncover unrelated but clinically significant variants
  3. Because incidental findings are guaranteed to be beneficial to the patient
  4. Because incidental findings can never be communicated back to patients
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Correct answer: Because patients may uncover unrelated but clinically significant variants

Genetic testing (especially broad panels or genome sequencing) may reveal incidental variants unrelated to the original indication; counseling ensures patients understand the possibility and can decide whether they wish to be informed of these findings.

Difficulty: Medium Question 20 of 20

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