What is a major limitation of genetic testing that must be discussed during pre-test counseling?
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Correct answer: Tests may yield variants of uncertain significance or false negatives
Genetic tests may detect variants whose significance is unclear (VUS), or may not detect all causative mutations (false negatives); discussing these limitations helps set realistic expectations.
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More Genetic Testing and Counseling questions
- Why is confidentiality especially important in genetic testing and counseling?
- Which of the following types of genetic testing might be discussed during pre-test counseling for a prenatal patient?
- What does the concept of “cascade testing” refer to in genetic testing and counseling?
- Which component is NOT typically part of a genetic counseling session?
- In the context of genetic testing and counseling, what is a variant of uncertain significance (VUS)?
- Which of the following is a reason a healthcare provider might recommend genetic counseling for adult-onset conditions?