Gene therapy basics · USMLE Step 1

Which of the following is a non-viral method of gene delivery in gene therapy?

  1. Adenoviral vector
  2. Lentiviral vector
  3. Cationic liposome (lipoplex)
  4. Adeno-associated virus (AAV)
Show answer and explanation

Correct answer: Cationic liposome (lipoplex)

Non-viral delivery methods include cationic liposomes (lipoplexes), electroporation, and gene guns, which introduce DNA without viral vectors, though generally at lower efficiency.

Difficulty: Medium Question 11 of 21

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