Gene therapy basics · USMLE Step 1

What is one ethical concern unique to germline gene therapy (modifying sperm, eggs, or embryos) as opposed to somatic cell gene therapy?

  1. The risk of immediate immune rejection of the edited cells
  2. Genetic changes can be passed on to future generations
  3. The generally lower efficiency of gene delivery to embryos
  4. An inability to correct the underlying disease-causing mutation
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Correct answer: Genetic changes can be passed on to future generations

Germline gene therapy could permanently alter the human germline, passing changes to future generations and raising ethical concerns about consent, long-term effects, and societal impact.

Difficulty: Medium Question 14 of 21

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