Which method can be used to detect a known deletion of several exons in a gene (copy-number variation) when sequencing fails to reliably quantify copy number?
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Correct answer: MLPA or a copy-number microarray assay
Techniques like MLPA or copy-number arrays (e.g., aCGH) are designed to detect deletions or duplications of exons or gene regions (copy-number variations), which sequencing may miss due to limitations in quantifying gene dosage.
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