Molecular diagnostics · USMLE Step 1

Which variant of PCR allows real-time monitoring of DNA amplification and quantification of DNA or RNA in a sample?

  1. Southern blot
  2. Real-Time (quantitative) PCR (qPCR)
  3. Sanger sequencing
  4. Loop-mediated isothermal amplification (LAMP)
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Correct answer: Real-Time (quantitative) PCR (qPCR)

Real-Time (quantitative) PCR (qPCR) uses fluorescent probes or dyes to measure DNA amplification as it happens, enabling quantification of DNA or RNA starting amounts in a sample.

Difficulty: Medium Question 2 of 21

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