Molecular diagnostics · USMLE Step 1

Which approach is best suited for rapidly typing multiple pathogens or resistance genes in a single patient sample?

  1. Single-target Sanger sequencing
  2. Multiplex PCR or multiplex qPCR
  3. Conventional culture only
  4. Karyotyping
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Correct answer: Multiplex PCR or multiplex qPCR

Multiplex PCR (or multiplex qPCR) uses multiple primer pairs or probes in one reaction to simultaneously amplify multiple target sequences — ideal for rapid detection of several pathogens or resistance genes in a single sample.

Difficulty: Medium Question 21 of 21

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