Gene Regulation and Epigenetics · USMLE Step 1

Which of the following processes is an example of epigenetic regulation in mammals?

  1. Single-nucleotide mutation introduced into a coding exon
  2. Genomic imprinting expressing only one parental allele
  3. Deletion of an entire gene from the chromosome
  4. Insertion of a transposable element into the genome
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Correct answer: Genomic imprinting expressing only one parental allele

Genomic imprinting is epigenetic: parent-of-origin-specific DNA methylation or chromatin modification leads to expression of only the maternal or paternal allele without changing the DNA sequence.

Difficulty: Medium Question 8 of 20

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