Gene Regulation and Epigenetics · USMLE Step 1

Which epigenetic mechanism is often reversible and thus a potential target for therapeutic intervention (e.g. in cancer)?

  1. DNA sequence mutation
  2. DNA methylation and histone modifications
  3. Chromosome deletion
  4. Gene duplication
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Correct answer: DNA methylation and histone modifications

Epigenetic marks such as DNA methylation and histone modifications are reversible and dynamic, making them attractive targets for therapies (e.g. DNMT inhibitors, HDAC inhibitors) in diseases like cancer.

Difficulty: Medium Question 15 of 20

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