Which chemical modification of DNA is most commonly involved in gene silencing when present in promoter CpG islands?
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Correct answer: Methylation of cytosine at CpG sites
Methylation of cytosines at CpG dinucleotides (forming 5-methylcytosine) in promoter regions is frequently associated with transcriptional repression of the associated gene.
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More Gene Regulation and Epigenetics questions
- Which family of enzymes is directly responsible for adding methyl groups to DNA during establishment of DNA methylation patterns?
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